Keep an eye on Intently (one)crofelemer boosts levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Crofelemer has the prospective to inhibit CYP3A4 at concentrations expected during the intestine; unlikely to inhibit systemically since minimally absorbed.fentanyl intranasal and diazepam both raise sedat